Norpill 1 Tablet

Indications

• Emergency contraception to prevent pregnancy after unprotected intercourse.
• Should be taken as soon as possible, preferably within 12 hours, and no later than 72 hours (3 days).
• Recommended in cases of:
  • No contraceptive method used.
  • Missed consecutive contraceptive pills.
  • Condom failure (broken, slipped, or not used).
  • Suspected expulsion of intrauterine device.
  • Vaginal diaphragm or contraceptive cap displacement.
  • Failure of coitus interruptus or rhythm method.
  • Sexual assault (rape).

Composition

• 15 mg tablet: Each contains 15 mg Levonorgestrel.
• 0.75 mg tablet: Each contains 0.75 mg Levonorgestrel (pack of 2 tablets).

Description

• Emergency contraceptive for women, not for regular use.
• Also known as “Post-Coital Pill” or “Morning After Pill.”
• Must be used within 72 hours of unprotected intercourse.

Pharmacology

• Levonorgestrel suppresses gonadotropins, inhibiting ovulation.
• Binds to progesterone and androgen receptors, reducing GnRH release.
• Prevents LH surge, follicle rupture, and ovum release.
• More effective if taken before ovulation.
• May also prevent implantation if fertilization has occurred.

Dosage & Administration

• 15 mg tablet: Single dose, taken as soon as possible within 72 hours.
• 0.75 mg tablets: First tablet within 72 hours, second tablet 12 hours later.
• Oral administration with water.
• If vomiting occurs within 3 hours, another tablet should be taken immediately.
• After use, barrier contraception (condom, spermicide, cervical cap) is recommended until next menstrual period.
• Continue regular contraceptive pills if already in use.

Interactions

• Effectiveness reduced by anticonvulsants (phenobarbital, phenytoin, primidone, carbamazepine), rifampicin, griseofulvin, and other enzyme-inducing drugs.

Contraindications

• Hypersensitivity to Levonorgestrel or excipients.
• Not indicated in existing pregnancy.
• Not recommended in ectopic pregnancy history, salpingitis, or severe digestive disorders affecting absorption.

Side Effects

• Nausea, vomiting, dizziness, fatigue, headache.
• Abdominal pain, breast tenderness.
• Menstrual changes (early, delayed, or irregular bleeding).

Pregnancy & Lactation

• Not effective if implantation has already occurred.
• No evidence of teratogenic effects if pregnancy continues.
• Levonorgestrel is secreted in breast milk; breastfeeding should be avoided for several hours after intake.

Precautions & Warnings

• For occasional use only; not a substitute for regular contraception.
• Menstrual period may occur earlier or later than expected.
• Pregnancy test recommended if menstruation is delayed >5 days or abnormal bleeding occurs.
• Does not protect against sexually transmitted infections (STIs).
• Medical advice recommended for ongoing contraception.

Overdose Effects

• No acute toxicity reported.
• Efficacy not guaranteed if doses are missed.