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Description
- Chronic obstructive pulmonary disease (COPD)
- Asthma (allergic and cardiac asthma)
- Pulmonary fibrosis
- Pulmonary tuberculosis
Composition (per 5 ml syrup)
- Vitis vinifera extract 0.72 g
- Cinnamomum zeylanicum 13.07 mg
- Elettaria cardamomum 15.07 mg
- Mimusops elengi (Maua ferrea) 15.07 mg
- Aglaia roxburghiana 15.07 mg
- Satureja lappa 13.07 mg
- Piper longum 10.07 mg
- Piper nigrum 10.07 mg
Description
- Classical polyherbal Ayurvedic preparation rich in resveratrol and bioflavonoids (proanthocyanidins).
- Vitis vinifera (grape) is the principal herb, known for antioxidant and anti-inflammatory properties.
- Contains proanthocyanidins, anthocyanins, flavonoids, resveratrol, and triterpenes with therapeutic benefits in respiratory and cardiovascular conditions.
Pharmacology
- Proanthocyanidins protect cell membranes by neutralizing free radicals, strengthen capillary walls, and reduce histamine release.
- Resveratrol: antioxidant, anti-inflammatory, cardioprotective. Inhibits LDL oxidation, platelet aggregation, and smooth muscle proliferation.
- Demonstrated efficacy in COPD and asthma by reducing inflammatory mediators and preserving vascular endothelial growth factor (VEGF).
- Aglaia roxburghiana triterpenes show potent anti-inflammatory activity.
- Pharmacokinetics: Resveratrol absorbed from GI tract, metabolized to glucuronide and sulphate conjugates, excreted via urine.
Dosage & Administration
- Children under 12 years: 1–2 teaspoons (5–10 ml) twice daily after meals.
- Adults and ≥12 years: 3–4 teaspoons (15–20 ml) twice daily after meals for 4–6 weeks or as directed by physician.
Interactions
- Use cautiously with anticoagulants (warfarin, aspirin), NSAIDs, ACE inhibitors, or antiplatelet agents.
- Grape seed may increase bleeding risk.
- Proanthocyanidins may alter effects of antihypertensive medications.
Side Effects
- Generally safe in Ayurvedic use.
- Rare cases: stomach pain, headache, allergic reactions.
Pregnancy & Lactation
- Pregnant or breastfeeding women should consult a physician before use.
- No adverse effects reported in literature.
Precautions & Warnings
- Use with caution in hypertension, liver disease, alcohol dependence, and diabetes.
- Patients with medical conditions should consult a doctor before use.
- Probiotic products (e.g., Lactobacillus) should be taken 2 or more hours apart.
